{"metadata":{"accession":"A0A6H3AB43","id":"A0A6H3AB43_BACAN","source_organism":{"taxId":"1392","scientificName":"Bacillus anthracis","fullName":"Bacillus anthracis (anthrax bacterium)"},"name":"Heme sensor protein HssS","description":["Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood"],"length":458,"sequence":"MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTRLFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFIAIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQEFVSNVSHEFQSPLSSIQGFSKTLQTEKMSVEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKNIAIEFDVPDITIKGDENLLHQVWSNIFTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEEMDRIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK","proteome":"UP000000594","gene":"GBAA_3260","go_terms":[{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0000155","name":"phosphorelay sensor kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016772","name":"transferase activity, transferring phosphorus-containing groups","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016310","name":"phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ed5ddfc4745162f183328622157829c334589c3b","counters":{"domain_architectures":119765,"entries":27,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":3,"smart":3,"profile":2,"ssf":3,"cdd":3,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":119765}}}