{"metadata":{"accession":"A0A6D2WNS2","id":"A0A6D2WNS2_PANTR","source_organism":{"taxId":"9598","scientificName":"Pan troglodytes","fullName":"Pan troglodytes (Chimpanzee)"},"name":"Transforming growth factor beta activator LRRC33","description":["Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling"],"length":692,"sequence":"MELLPLWLCLGFHFLTMGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLILDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNRLSENYRETAAALHALRGLRRLDLSGNSLTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSAFEGLERLRELDLQRNYIFEIEGGAFDGLPELRHLNLAFNNLPCIVDFGLTQLRVLNVSYNVLEWFLAAGAEAAFELETLDLSHNQLLFFPLLPQHSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVNLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLNQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGPASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLTPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY","proteome":null,"gene":"NRROS","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"40a30f58aee67f4e4bd867613891433f7f3ab1d6","counters":{"domain_architectures":27,"entries":13,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":3,"profile":1,"panther":1,"prints":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":27}}}