{"metadata":{"accession":"A0A674MNB9","id":"A0A674MNB9_TAKRU","source_organism":{"taxId":"31033","scientificName":"Takifugu rubripes","fullName":"Takifugu rubripes (Japanese pufferfish)"},"name":"6-phosphofructokinase","description":["Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway"],"length":739,"sequence":"VRKMAALSWLGLGKMAALSWLGLGKMATLSWFNGLQFKVSLIHTRLGGTMIGSARCKAFTTREGRIAAAFNLVKKGITNLCVCGGDGSLTGANIFRSEWSGLLAELVEKGRITDTLAKQHGHLNIVGLVGSIDNDFCGTDMTIGADSALHRIMEIIDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPKEGWEDRMCNRLESRTTGSRLNIIIIAEGAIDMNGKPITSTYVKDLVVKRLGYDTRLTVLGHVQRGGTPSAFDRTLSSRLGVEAVIALMEATPDTPACVIGLSGNQAVRLPLMECVEMTKLVQKCMNERRFDEAVKLRGGSFENNWNIYKLLAFQKPTNFTLAILNVGAPAAGMNSAVRSAVRLALIHGHKVYGVHDGFQGLAKGEMNWGNVAGWTGQGGSLLGTKRTLPEEHMENVVETIRKYKISALLVIGGFEGYEGVLQLFEARTHYEELCIPMCVVPATISNNVPGTDFSLGADTAVNSVMDCCDKIKQSASGTKSRVFVVETMGGYSGYLATTAGIATGADAVYIYEDPFNIHDLTTNVEHLTEKMKKDVQRGLVLRNEKCHEFYTTDFIHKLYSAEGKGIFDCRFNVLGHLQQGGAPSPFDRNFGTKLGVRAIQWLSQKLSENFRQDHVFANSSDTACVLGFSRKVISFIPVTELKAMTDFEHRMPKEQWWLKFRPILKMLAKYQISFCEYVPGEIEHVTRRSISIDSVF","proteome":"UP000005226","gene":"pfkla","go_terms":[{"identifier":"GO:0003872","name":"6-phosphofructokinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006096","name":"glycolytic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006002","name":"fructose 6-phosphate metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"20ff398270d8943567bf1df83c8dee6c98fdb133","counters":{"domain_architectures":8630,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"cathgene3d":2,"ssf":1,"ncbifam":1,"pirsf":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":8630}}}