{"metadata":{"accession":"A0A673FMA5","id":"A0A673FMA5_9TELE","source_organism":{"taxId":"307959","scientificName":"Sinocyclocheilus rhinocerous","fullName":"Sinocyclocheilus rhinocerous"},"name":"Core-binding factor subunit beta","description":["Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation"],"length":201,"sequence":"MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPANLHGDQRQAPSREYVDFERETGKVYLKAPMILNGVCVIWRGSIDLQRLDGMGCLEYDDERAQHEDALAQAAFEETRRRTRDFEDRDRSHREDMEQMPMAQLSHLITQEPRRQQDPSPGSNMGNTDDHKMR","proteome":"UP000472270","gene":"LOC107715210","go_terms":[{"identifier":"GO:0003713","name":"transcription coactivator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4f81a3cba7f5268c02d3532614e1c5139b41efa7","counters":{"domain_architectures":2162,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":2162}}}