{"metadata":{"accession":"A0A671YPY0","id":"A0A671YPY0_SPAAU","source_organism":{"taxId":"8175","scientificName":"Sparus aurata","fullName":"Sparus aurata (Gilthead sea bream)"},"name":"Transcription and mRNA export factor ENY2","description":["Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery","Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery"],"length":96,"sequence":"MSKDSQMRAAINQKLIEMGERERLKELLRAKLVECGWKDQLKAHCKDVIKEKGLEHVTVEDLVTDVTPKGRALVPDSVKKELLQRIRAFLAQHATL","proteome":"UP000472265","gene":"ENY2","go_terms":[{"identifier":"GO:0003713","name":"transcription coactivator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006406","name":"mRNA export from nucleus","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045893","name":"positive regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000124","name":"SAGA complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ba9455d725df3ff238858c99315bda05780bc904","counters":{"domain_architectures":3443,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"panther":1,"hamap":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":3443}}}