{"metadata":{"accession":"A0A671WR96","id":"A0A671WR96_SPAAU","source_organism":{"taxId":"8175","scientificName":"Sparus aurata","fullName":"Sparus aurata (Gilthead sea bream)"},"name":"tryptophan 5-monooxygenase","description":["Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis"],"length":482,"sequence":"MYSNKNEGPRRGRSFDSMNIGFEEKLLNNEINKSTFTKIEENSEKKNTSEKGRATIIFSLKNEVGGLVKALRLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNHEQLNEIIHLLRKHVNVVDMDPPDNSCLHEDGKYMYDVPWFPKKISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMAFKHGDPIPRIEFTEEEVKTWGVVYRELNKLYPTHACREYLKNLPLLSKYCEFREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSVQKLATCYFFTVEFGLCKQEGQLRAYGAGLLSSISELKHALSGNARIMPFDPKVTSKQECIITTFQDVYFVSESFEEAKVKMREFAKTIKRPFTVRYNPYTQSVDVLKDTPSINSVVEELRHELDIVGDALIRLNKQLGV","proteome":"UP000472265","gene":"TPH1","go_terms":[{"identifier":"GO:0004497","name":"monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009072","name":"aromatic amino acid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016714","name":"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004510","name":"tryptophan 5-monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042427","name":"serotonin biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"81f0c7016fbca3db96a13b561765988daca7de37","counters":{"domain_architectures":2933,"entries":24,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":2,"cdd":2,"pfam":2,"profile":2,"pirsf":1,"panther":1,"ncbifam":1,"prints":1,"prosite":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":2933}}}