{"metadata":{"accession":"A0A671FQ60","id":"A0A671FQ60_RHIFE","source_organism":{"taxId":"59479","scientificName":"Rhinolophus ferrumequinum","fullName":"Rhinolophus ferrumequinum (Greater horseshoe bat)"},"name":"Acyl-coenzyme A thioesterase 8","description":["Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation"],"length":317,"sequence":"MTSPQAPEDGQGSGDPSGDLRSVLVTSVLNLEPLDEDLFRGRHYWIPTTQRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKVPVLYQVERTRTGTSFSVRSVKAVQHGKPIFVCQASFQQAQPSPVQHQCSMPAVPPPEELLDHEALIAQYLRDPNLHEKYRVGLNRIAAQEVPIEIKMVNPPTLNKLQNREPNQMFWVRARGHIGEGDIKMHCCVAAYISDYAFLGTALLPHHYQHKVCFMASLDHSMWFHAPFRADHWMLYECKSPWAGGSRALVHGQLWRRDGVLAVSCSQEGVIRVKPRVSESKL","proteome":"UP000472240","gene":"ACOT8","go_terms":[{"identifier":"GO:0047617","name":"fatty acyl-CoA hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006637","name":"acyl-CoA metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"21534189134aa2c19bc618fde6f3102a006e91ff","counters":{"domain_architectures":17805,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":2,"pfam":2,"panther":1,"ncbifam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":17805}}}