{"metadata":{"accession":"A0A669P7N2","id":"A0A669P7N2_PHACC","source_organism":{"taxId":"9054","scientificName":"Phasianus colchicus","fullName":"Phasianus colchicus (Common pheasant)"},"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase","description":["Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier"],"length":1219,"sequence":"MAGAQPGVHALQLKPVCVSDTLKKGVKFVKWDDDSTVVTPIILRTDPQGFFFYWTDQNKETELLDISLVKDARCGKHARAPKDPKLRELLDAGNVGSRLENRMITVVYGPDLVNISYLNLVAFQEDIAKEWSDEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACNLPSSRNDSIPQDDFTPDVYRVFLNNLCPRPEIDHIFSEFGAKSKPYLTVDQMMEFINLKQRDPRLNEILYPPLKQEQVQQLIEKYEPNSNLAKKGQISVDGFMRYLSGEENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMDPLEKYPLEPGVPLPSPMDLMYKILVKNKKKSHKSADGSAKKKLSEQASNTCSDTSSMFEPSSPGAGEAEIESDDDDDYDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEVSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNFQTVDLSMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTESIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKALKTKTSQGNAVNPVWEEETIVFKKVVLPTLACLRLAVYEEGGKFIGHRILPVSAIRPGYHYICLRNERNQPLTLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEVDHGDAPSEANSEPRPAPAENGVNHTASLTPKPATQVVHSQPTPGLVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTAKYNEIQNDYLRRRAVLEKTAKRDSKKRSETGSPDHGSSTIEQELAALDSEMTQKLVELKEKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNSQLKKLKETCEKEKKELKKKMDKKRQEKITEAKSKDKNQMEEEKTEMIRSYIQEVVQYIKRLEDAQSKRQEKLIEKHKEIRQQILDEKPKLQVELDQEYQDKFKRLPLEILEFVQEAMKGKISEDGDHSSAPSSLASDSGKSNHKPLQSEEELEEDNSEKVFDTTF","proteome":"UP000472261","gene":"PLCB1","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016042","name":"lipid catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9fdc453e04964edb563b34885b1f1a4cf4dbc4fa","counters":{"domain_architectures":1689,"entries":41,"isoforms":0,"proteomes":1,"sets":7,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":5,"pfam":5,"cdd":4,"profile":3,"smart":3,"pirsf":1,"panther":1,"prints":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":1689}}}