{"metadata":{"accession":"A0A668TDN1","id":"A0A668TDN1_OREAU","source_organism":{"taxId":"47969","scientificName":"Oreochromis aureus","fullName":"Oreochromis aureus (Israeli tilapia)"},"name":"EF-hand domain-containing protein","description":["Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases"],"length":149,"sequence":"QADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK","proteome":"UP000472276","gene":"LOC116315545","go_terms":[{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4403894abd2a553d27123253401701775ffd4bde","counters":{"domain_architectures":58144,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"smart":1,"pfam":1,"cdd":1,"panther":1,"prosite":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":58144}}}