{"metadata":{"accession":"A0A667G0X7","id":"A0A667G0X7_LYNCA","source_organism":{"taxId":"61383","scientificName":"Lynx canadensis","fullName":"Lynx canadensis (Canada lynx)"},"name":"Neurogenic locus notch homolog protein 2","description":["Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells"],"length":2471,"sequence":"MPALLPAPLWALLALWLCRAAPARALQCRDSYEPCVNEGICVTYHNGTGYCKCLEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAPGFTGDDCQYSTAHPCFVSHPCLNGGTCHVRSRDDYECTCQVGFTGKLCQWTDACLSHPCANGSTCTTVANQFSCRCLAGFTGQKCETDVNECDIPGQCQHGGTCLNLLGSYQCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGITCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLRGYTGPRCELDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCVHGVCMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCLCPEGPHHPSCYSQVNECLSSPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFESYTCLCAPGWQGQRCTIDIDECVSKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCVDGVNTFSCLCHPGFIGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHEINECNSHPCLNEGVCVDGLGTYRCTCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQEKAESRCLCPSGWAGAYCDVPNVSCEVAAFHRGVSIDHLCQHSGICINAGNSHHCQCPLGYTGSYCEEQLDECSSNPCQHGATCRDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCVDLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPHMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPRCFCPNPQDCESGCASSPCQHGGSCYPQRQPPYYFCQCSPPFWGSHCELYTAPTSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTAECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADRPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLRTNLQIKRDSQGVLMVYPYYGEKSAAMKKQRMIRRSLPGDQEQEVVGSKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPKGTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDSSNHKRREPVGQDAVGLKNLSVQVSEANLIGSGTSEHWVDDEGPQPKKAKAEDEALLSEEDDAIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDMSDEDEDGEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKPRRPNTKSAMPTSLPNLAKEAKDAKGNRRKKSLSDKGQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGANTVLPSVSQLLSHHHIVPPGSGSTGSLGRLHPVTVPADWMNRMEMNETQYNEMFSMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSISQPAGTPQPQSNCPPPVAGPVPTMYQIPEMARLPNMAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPRSNMQVYA","proteome":"UP000472241","gene":"NOTCH2","go_terms":[{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030154","name":"cell differentiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0007219","name":"Notch signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007275","name":"multicellular organism development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050793","name":"regulation of developmental process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0038023","name":"signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006915","name":"apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0071228","name":"cellular response to tumor cell","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0043235","name":"receptor complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"23dd2044d5ea7be6f786f30bb1e1006cd4c14af6","counters":{"domain_architectures":2,"entries":57,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"profile":4,"cathgene3d":4,"smart":7,"ssf":4,"pfam":9,"cdd":2,"pirsf":1,"panther":1,"prints":4,"prosite":4,"interpro":17},"proteome":1,"taxonomy":1,"similar_proteins":2}}}