{"metadata":{"accession":"A0A665W9Y0","id":"A0A665W9Y0_ECHNA","source_organism":{"taxId":"173247","scientificName":"Echeneis naucrates","fullName":"Echeneis naucrates (Live sharksucker)"},"name":"Endonuclease 8-like 1","description":["Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC"],"length":418,"sequence":"MPEGPELHLASLYVNKMCKGVVFTGPVRKSEVSKNPDVPFTSEAYFITAVSRGKEVKLTLTPIKTDEPKVRVKAGQTEKPMDVVFRFGMSGYFRLTKEDELPKHAHLRFYTKETPCKVLSFVDARRFGSWEPNGTWQPARGPCIMFEYKSFRENVVSHLSDSAFDRPICEVLLNQKYFNGIGNYLRAEILFRLKIPPFVSARTVLKGLESEDPSECAKPVKNEIADTKMPVCSKKEKVKAEVGDLLRLCHTVPLEVVNLGGKGYDPEKSDYSVFEAWLQCYYVDGMKSMRDHNGRTIWFEGDPGALAPKNSKSPKAKKRAKKEDDHDYTEKKKLVRNASKDSTKRAVKQEASAKTRKKQKDVHGKRARSKKRHTDKSQEVNTPSHLEKGTTARRRRSSVEPAGGSQRRSSRLTRQNNQ","proteome":"UP000472264","gene":"neil1","go_terms":[{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a3c48f027a33489e7a21b1cb4e22b7d0c8aee9f7","counters":{"domain_architectures":875,"entries":15,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cdd":1,"cathgene3d":2,"profile":1,"smart":1,"ssf":3,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":875}}}