{"metadata":{"accession":"A0A663MI36","id":"A0A663MI36_ATHCN","source_organism":{"taxId":"194338","scientificName":"Athene cunicularia","fullName":"Athene cunicularia (Burrowing owl)"},"name":"Set1/Ash2 histone methyltransferase complex subunit ASH2","description":["Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B"],"length":568,"sequence":"MVDVAAALDTESANGKDALEAAGDGSEVLDAQAGSVDEENGRQLGEIELQCGICTKWFTADTFGIDTTSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMCKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLANIGPAYDNQKQNNAVSTSGNLNGGASLGGGIAASGSGKGRGAKRKQQDGGTTGTAKKTRSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEISMDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDILGFYISLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQAPGSQIIFFKNGASQGIAFKDIFEGVYFPAISLYKGCTVSINFGPYFKYPPRDITYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP","proteome":"UP000472269","gene":"ASH2L","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0048188","name":"Set1C/COMPASS complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"830f1293ba0349f2cfb7983c94070ba9aa3fbe10","counters":{"domain_architectures":1617,"entries":18,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":2,"pfam":3,"ssf":1,"profile":1,"smart":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":1617}}}