{"metadata":{"accession":"A0A552U732","id":"A0A552U732_9SPHN","source_organism":{"taxId":"2593303","scientificName":"Glacieibacterium frigidum","fullName":"Glacieibacterium frigidum"},"name":"Methylated-DNA--protein-cysteine methyltransferase","description":["Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated"],"length":362,"sequence":"MHTDPQACYAAMLIRDPAADGRFFVCVRTTGIFCRPVCPARTPFLKNVSFVATAADAVAAGYRACKRCRPETARGSPAWTGSAASVARALTLIEKGGLDETRVDALGDRLGLGERQVRRLFKQHVGAPPVVVAQAKRLAAAAPLIDEGTMPMAQVALAAGFGSIRRFNEVWAGVHGETPAARRRRIAKGTPVQLTLTRHTAPVGDLLIVTDAEGALRALDFADYEARMRTLLGRHYGAVTLTDGPAPPAVVAALDAYFAGDATALDGLTVKTGGSEFQRSVWAALRAIPAGTTTGYGALAAMLGKPGAARAVGLANGSNPVGIVVPCHRVIGANGTLTGYAGGVERKRWLLEHEGALARAIL","proteome":"UP000317894","gene":"FMM06_09815","go_terms":[{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003908","name":"methylated-DNA-[protein]-cysteine S-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"70e0ff62b92abd7ed0f0ad6d5845585d22fa1f2f","counters":{"domain_architectures":3423,"entries":29,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":4,"profile":1,"smart":1,"pfam":4,"cdd":1,"panther":1,"hamap":1,"ncbifam":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":3423}}}