{"metadata":{"accession":"A0A507ZP21","id":"A0A507ZP21_9GAMM","source_organism":{"taxId":"1706195","scientificName":"Marilutibacter aestuarii","fullName":"Marilutibacter aestuarii"},"name":"Bifunctional ligase/repressor BirA","description":["Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon"],"length":344,"sequence":"MRGSLNLGGAVIEERELLERLMAGPVSGDALARASGLSRAAVWKRIQALRDAGVPIQAQAGRGYRLEQPMDLLSPAAILGALDPATAASVHGLEVEWSLDSTNSALLRRAPPVAPGRVEVLMAERQTGGRGRRGRHWASPLAAHLYLSLARGFEGGLARLGGLSLVAGIAVAEALHAFGVDAARLKWPNDIVVEAADGLRKLGGVLVEGGGEHAGPVRAVIGIGLNVRMPPAEAAAIDQPWCDLEALAGPGVDRNRVAATLLSHLLPALDAFDAEGLAPFMARHAALDVLAGRAVRLHGEGVAVRTGTALGLAADGALRVRLDSGECCDVHSGEVSVRRLESPA","proteome":"UP000318212","gene":"birA","go_terms":[{"identifier":"GO:0036211","name":"protein modification process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004077","name":"biotin--[biotin carboxyl-carrier protein] ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e323a284b0f9347a27dee67a68aa1033e00ba978","counters":{"domain_architectures":8512,"entries":25,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":3,"cdd":1,"ssf":3,"profile":1,"hamap":1,"ncbifam":2,"panther":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":8512}}}