{"metadata":{"accession":"A0A4W2HYB8","id":"A0A4W2HYB8_BOBOX","source_organism":{"taxId":"30522","scientificName":"Bos indicus x Bos taurus","fullName":"Bos indicus x Bos taurus (Hybrid cattle)"},"name":"Cytoplasmic tRNA 2-thiolation protein 1","description":["Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position"],"length":347,"sequence":"MPAPQCASCHKARAALRRPRSGQALCGSCFCAAFEAEVLHTVVAGRLLPPGAVVAVGASGGKDSTVLAHVLRELAPRLGISLHLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYADLFGGWTMDAVARSTAGSGRSRACCTFCGVLRRRALEEGARLVGATHVVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQLASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKMLEAARPSAVLDLVHSAERLALAPTARPPPPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEGPPREPQPSRPLTSEPVPDF","proteome":"UP000314981","gene":"LOC113876127","go_terms":[{"identifier":"GO:0008033","name":"tRNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000049","name":"tRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0002098","name":"tRNA wobble uridine modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0034227","name":"tRNA thio-modification","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ecea3fd540da2a3be05a58e475a5fac2d5801c14","counters":{"domain_architectures":3042,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"pfam":2,"pirsf":1,"hamap":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":3042}}}