{"metadata":{"accession":"A0A4V5PBG0","id":"A0A4V5PBG0_MONMO","source_organism":{"taxId":"40151","scientificName":"Monodon monoceros","fullName":"Monodon monoceros (Narwhal)"},"name":"G-protein coupled receptors family 1 profile domain-containing protein","description":["G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction"],"length":357,"sequence":"MSPPNQSVEGLLQGAPNRSLNAIETPGAWDPGTLQALKISLAVVLSIITLATVLSNAFVLTTIFLTRKLHTPANYLIGSLAMTDLLVSILVMPISIAYTTTHTWSFGQLLCDIWLSSDITCCTASILHLCVMALDRYWAITDALEYSKRRTAGRAAAMIAIISAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYFPSVLLIILYGRIYTAARNRILNPPSLYGKRFTTARLTTGSAGSSLCSLSPSLHEGHSHSAGSPRFFNHVKIKLADSVLERQRISAARARKATKTLGIILPERGKPLKPWGSFWAPLPSAGCPSLLHLWSSPSAGTPAGSTQPFLTFSPG","proteome":"UP000694561","gene":"HTR1D","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004993","name":"G protein-coupled serotonin receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006939","name":"smooth muscle contraction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007268","name":"chemical synaptic transmission","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0040012","name":"regulation of locomotion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042310","name":"vasoconstriction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0050795","name":"regulation of behavior","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005886","name":"plasma membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":340616,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"profile":1,"pfam":1,"panther":1,"prints":2,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":340616}}}