{"metadata":{"accession":"A0A452R3X1","id":"A0A452R3X1_URSAM","source_organism":{"taxId":"9643","scientificName":"Ursus americanus","fullName":"Ursus americanus (American black bear)"},"name":"DNA repair nuclease/redox regulator APEX1","description":["Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends"],"length":318,"sequence":"MPKRGKKGAVAEDGEEPKIEPEAKKSKAGTKKNEKEAAGEGPVLYEDPPDQKTAPSGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELSGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDAFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL","proteome":"UP000291022","gene":"APEX1","go_terms":[{"identifier":"GO:0004518","name":"nuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004519","name":"endonuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"01d417aef5428373d5752df5b6a37440f3868628","counters":{"domain_architectures":156843,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"profile":1,"pfam":1,"panther":1,"ncbifam":2,"prosite":3,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":156843}}}