{"metadata":{"accession":"A0A452QF49","id":"A0A452QF49_URSAM","source_organism":{"taxId":"9643","scientificName":"Ursus americanus","fullName":"Ursus americanus (American black bear)"},"name":"Acetylcholine receptor subunit epsilon","description":["After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane"],"length":491,"sequence":"MAGALLGALLVLQLLGRGRGRNEELRLYHHLFDDYDPERRPVKEPEETVTITLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGVETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGYVSWLPPAIYRSTCAVEVTYFPFDWQNCSLVFRSQTYSAEEVDFVFAVDDAGETISKIEIDTEAYTENGEWAIDFCPGLIRRPDRASAGGPGVVDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPMLGRYLIFVMVVATIIVMNCVVVLNVSLRTPTTHTISPRLRHVLLELLPRLLGSGAPPEAPRTTSPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRHGVWTAALCQSLGSAAPEVRCCVDAVNFVAESTREREASGEEVSDWVRMGKALDNICFWAALGLFGVGSSLIFLGGYFNQVPELPYPPCM","proteome":"UP000291022","gene":null,"go_terms":[{"identifier":"GO:0005230","name":"extracellular ligand-gated monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0034220","name":"monoatomic ion transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0022848","name":"acetylcholine-gated monoatomic cation-selective channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045211","name":"postsynaptic membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f0f65eb78714613543b62ad4efdee53cc781e40a","counters":{"domain_architectures":69545,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"pfam":2,"panther":1,"prints":2,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":69545}}}