{"metadata":{"accession":"A0A452FCN3","id":"A0A452FCN3_CAPHI","source_organism":{"taxId":"9925","scientificName":"Capra hircus","fullName":"Capra hircus (Goat)"},"name":"Mediator of RNA polymerase II transcription subunit 18","description":["Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors"],"length":208,"sequence":"MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFVDHEMVFLLKGQQASPFVLRARRSLDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVARGHLFRKGIMKIVVYKIFRILVPGNTDNTEALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM","proteome":"UP000291000","gene":"MED18","go_terms":[{"identifier":"GO:0003712","name":"transcription coregulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016592","name":"mediator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"858830eac77a5ee060762aaa591b3146b26bc6a4","counters":{"domain_architectures":2850,"entries":4,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"panther":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":2850}}}