{"metadata":{"accession":"A0A3Q7TW56","id":"A0A3Q7TW56_VULVU","source_organism":{"taxId":"9627","scientificName":"Vulpes vulpes","fullName":"Vulpes vulpes (Red fox)"},"name":"DNA repair and recombination protein RAD54B","description":["Multifunctional ATPase that could play with RAD54, a redundant role in homologous recombination (HR), a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Could act as a molecular motor during the homology search and guide RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Once DNA strand exchange occured, could dissociate RAD51 from nucleoprotein filaments formed on dsDNA. May also function as a molecular adapter, promoting MDM2-MDM4 heterodimerization to facilitate the ubiquitin-dependent degradation of p53, thereby modulating the cellular decision between cell cycle arrest and progression in response to DNA damage"],"length":744,"sequence":"MAYKLKELEKIEEGHRVMIGGKEVEVMGIISPDDFNSGRCFQLGRGSPAISSSSQAAKKCFSNPFKSVCKPSSKENRLGGFQDCKPRHDPHAPNSLVMSRPDNNHQWMFNKKGFPVVDVVIDPHLVYHLRPHQKEGIMFLYECVMGMRVNGRCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPVVKKTLIVTPGSLVNNWRKEFQKWLGSERIKIFPVDQDHKVEEFTRSPFYSVLIISYEMLLRSLDQIKNVKFGLLICDEGHRLKNSAIKTTAALISLSCEKRVILTGTPVQNDLQEFFALIDFVNPGILGSLSFYRRVYEEPIIISRQPSASEEEKKLGEKRAVELTCLTGLFILRRTQEVINKYLPPKIENVVFCRPGALQIELYRKLLNSQAVRFCLQGLLGNSPHLICIGALKKLCNHPCLLFKSIKERECSSTWDGKEEKSLYEGLVDVFPADYNPLMFTEEESGKLQVLLKLLAVIHELRPTEKVVLVSNYTQTLDILQEVCKRHGYTYTRLDGQTPVSQRQQIVDSFNSKYSSDFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKNPVHVYRLLTTGTIEEKIYQRQISKQDLSGAVVDLTKTSEHIPFSVEELKNLFTLHESSHCVTHDLLDCECTGDQDGTGDSLEKFPVSRNCQLGAHHQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERIRENVSFFFQNITNQSTAII","proteome":"UP001652641","gene":"RAD54B","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"191844a28300a3553039efbca8422ae9ce46237c","counters":{"domain_architectures":47586,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":3,"smart":2,"cdd":2,"pfam":2,"profile":2,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":47586}}}