{"metadata":{"accession":"A0A3Q7MX32","id":"A0A3Q7MX32_CALUR","source_organism":{"taxId":"34884","scientificName":"Callorhinus ursinus","fullName":"Callorhinus ursinus (Northern fur seal)"},"name":"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase","description":["Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway"],"length":278,"sequence":"MGRSSEWSKRTAGIQKSVLEKWTKQAKPQDTLDLCQLLNNDLAATVANHPRRFIGLGTLPMQAPELAVKEMERCVKELGFPGVQIGSHINEWNLNAPELFPVYAVAEKLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTTAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFNMRPDLCAQDNPTNPKKYLGSFYTDSLVHDPLALKLLTDVIGKDQVILGTDYPFPLGELEPGKLIESIEEFDAETKDKLKAGNALAFLGLERKQFE","proteome":"UP000286641","gene":"ACMSD","go_terms":[{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016831","name":"carboxy-lyase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"893f5bb5f82dba8c120faf41d4a977fe8fba5622","counters":{"domain_architectures":79182,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":79182}}}