{"metadata":{"accession":"A0A3Q3BLI7","id":"A0A3Q3BLI7_KRYMA","source_organism":{"taxId":"37003","scientificName":"Kryptolebias marmoratus","fullName":"Kryptolebias marmoratus (Mangrove killifish)"},"name":"Ferredoxin-2, mitochondrial","description":["Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6"],"length":196,"sequence":"MAASAAVRTSMALTLRFNRVIPQCSTCPLSRLKRCMNSRANTQRRGSFDSFRTINRHLQTSICLHQGEEGSSNAEEPDDVVNVVYIDRSGQRIPVKAKVGDNVLFLAHKHGIDLEGACEASLACSTCHVYVSAAHFDKLPEPEETEDDMLDMAPMLQENSRLGCQIVLTPELDGMELTLPKVTRNFYVDGHVPKPH","proteome":"UP000264800","gene":null,"go_terms":[{"identifier":"GO:0051536","name":"iron-sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051537","name":"2 iron, 2 sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140647","name":"P450-containing electron transport chain","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fdc269cf1d8d48c0a366de0336ed1429d1ca6486","counters":{"domain_architectures":45276,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"cdd":1,"pfam":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":45276}}}