{"metadata":{"accession":"A0A3Q2VVJ2","id":"A0A3Q2VVJ2_HAPBU","source_organism":{"taxId":"8153","scientificName":"Haplochromis burtoni","fullName":"Haplochromis burtoni (Burton's mouthbrooder)"},"name":"Thromboxane-A synthase","description":["Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE"],"length":561,"sequence":"MQAAGDFLNVFNTETSKISVTLFLIFLGLLYWYSVRPFSVLSRCGIKHPKPVPFFGNLFMFQQGFFKPLNDLVKTYGKVCGYYLGRTPVIVVADPDMLRQLLVKDFSNFPNRNKFVFAKKPASDCLLQLRNEQWKRVRSVLTPSFSAAKMKEMVPLINTAIDTLMKNLHVYAESGEAFDIHRYFGYFTMDVIASVAFATQVDSQNNPDDPLVQHAQMAFTNDFFKSVLLLFFAFPSIMAPLSRFIPNKRRDKMSHFFINSIHKIIKQREEQPPEQRRRDFLQLMLDARTTEERVSLERFDTSNDTDEISDNNQQTQSSGKVQENDLPHSQEPSVRRPQKKMMTEDEIVGQAFIFLLAGYETSSSTLAFTCYLLALHPECQLKVQKEVDDFYTRHESPDYTNVQELKYLDMVVCEALRLYPPGFRFAREVDHDCVVNGQFLPKGITVEIPAGFLHYDPEHWPEPEEFIPERFTPEAKASRHPFVYLPFGAGPRNCVGMRLAQLEIKMALVRLFQSFSIVACSETKVPLELKSSSTLGPKNGIYVKITRRDQRDGPFISPSDD","proteome":"UP000264840","gene":null,"go_terms":[{"identifier":"GO:0004497","name":"monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016705","name":"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0020037","name":"heme binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e3099b6a964c63c7481beb4be664022a4b67f85a","counters":{"domain_architectures":38192,"entries":12,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"ssf":1,"panther":1,"prints":2,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":38192}}}