{"metadata":{"accession":"A0A3Q2HW60","id":"A0A3Q2HW60_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"m7GpppN-mRNA hydrolase","description":["Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts"],"length":446,"sequence":"MHCSCCGSSSWRLNGWRFPAASWTISAEVLGVFFKAPLRIKCRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPAKPTVEKLSRTKFRHSQQLFPEGSPGDQWVKHRQPLQQKPYNNHSETSDLLKAKNQSLRGNGRKQYQDSPNQKKRANGVHSQPAKQQNPLMKCEKKLHPRKLQDNFETDAVYDLPCSSEDQFLEHAEGQSVACNGHCKFPFSSRTFLSFKFDHNAIMKILDL","proteome":"UP000002281","gene":"DCP2","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030145","name":"manganese ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140933","name":"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000184","name":"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000290","name":"deadenylation-dependent decapping of nuclear-transcribed mRNA","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6a34304c0443642199915b93850948b84d4fe523","counters":{"domain_architectures":4156,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"ssf":2,"cathgene3d":2,"smart":1,"profile":1,"cdd":1,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":4156}}}