{"metadata":{"accession":"A0A3Q1LRN0","id":"A0A3Q1LRN0_BOVIN","source_organism":{"taxId":"9913","scientificName":"Bos taurus","fullName":"Bos taurus (Bovine)"},"name":"Adenylate cyclase type 8","description":["Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells","Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling"],"length":1187,"sequence":"MELSDVRCLSGSEELYTIHPTPPAGDSGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGGGGNGSSSKASDPGGGGPNHHHASQLSGDSALPLYALGPGERAHGTGGPKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLMQVVLQAVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGAPAEGADKPELP","proteome":"UP000009136","gene":"ADCY8","go_terms":[{"identifier":"GO:0009190","name":"cyclic nucleotide biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004016","name":"adenylate cyclase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006171","name":"cAMP biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005886","name":"plasma membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016849","name":"phosphorus-oxygen lyase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"be9de598556fea8c7d5ac124967124d6d9aa6104","counters":{"domain_architectures":3474,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"pfam":2,"cdd":1,"profile":1,"panther":1,"pirsf":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":3474}}}