{"metadata":{"accession":"A0A3Q1G042","id":"A0A3Q1G042_9TELE","source_organism":{"taxId":"80966","scientificName":"Acanthochromis polyacanthus","fullName":"Acanthochromis polyacanthus (spiny chromis)"},"name":"DNA replication licensing factor MCM5","description":["Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity","Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"],"length":694,"sequence":"MSGFDDPGVYYSDSFGGGEGPGVDEGGQKRIQIKKRFREFLRQFREGTDRTGFTYKYRDELKRHYTLGEYWVEVEMEDLASFDEDLSDCLYKLPSENLPLSEQVSRLVKVHGIIISATAVKAKATKVCLQCRGCRASINNVPLPPGLQGYALPRKCNNENAGKMKCPVDPYFIIPDRCVCVDFQTLRLQESPDAVPHGEMPRHLQLYCDRYLCDRVVPGNRVTIMGIYSIKKMAAAKAKGKEKGVGVGIRASYLRVVGIQVDTEGAGRGATGSVSPQEEEELRGLAASPKVYESLAHSVAPSIYGSDDLKKAITCLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPSTRGFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTKGEDNIDFMPTILSRFDMIFIIKDQHDQQRDMTLARHVMNVHLSAQTQTEGVEGEIPLATFKKYIAYARTKCGPRLSAAAAEKLKNRYVVMRSGAREHERETDKRPSIPITVRQLEAVVRIAESLAKMKLQAVAGEEEVDEALRLFQVSTLDAALSGSLSGVEGFTSQEDQEMIARVEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIYKVLHLMLRRGELQHRMQRKVLYRVK","proteome":"UP000257200","gene":null,"go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003688","name":"DNA replication origin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0042555","name":"MCM complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e8a458b3d2634053f3feb31302f6d055963c90a8","counters":{"domain_architectures":337,"entries":25,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"smart":1,"pfam":4,"profile":1,"cdd":1,"panther":1,"prosite":1,"prints":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":337}}}