{"metadata":{"accession":"A0A3Q1AZU7","id":"A0A3Q1AZU7_AMPOC","source_organism":{"taxId":"80972","scientificName":"Amphiprion ocellaris","fullName":"Amphiprion ocellaris (Clown anemonefish)"},"name":"Dicarboxylate carrier UCP2","description":["Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production. May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides"],"length":306,"sequence":"MVGLKPSDVPPPLGVKMASAGAAACIADIVTFPLDTAKVRLQIQGEKTAVGGIRYRGVFGTISTMIRTEGPRSLYNGLVAGLQRQLCFASIRIGLYDNVKNFYTGGKDNPGVLIRILAGCTTGAMAVSFAQPTDVVKVRFQAQMNLDGVARRYNGTMQAYKHIFQNEGIRGLWKGTLPNITRNALVNCTELVTYDLIKEAILKHKLMSDNLPCHFVSAFGAGFVTTVIASPVDVVKTRYMNSPPGQYKSAINCAWTMLTKEGPSAFYKGFVPSFLRLGSWNVVMFVSFEQIKRAMMVSKKRMEATN","proteome":"UP001501940","gene":null,"go_terms":[{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"e037822792ef5f5d7967370632f8bf737b916266","counters":{"domain_architectures":125498,"entries":10,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"profile":1,"pfam":1,"cathgene3d":1,"ssf":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":125498}}}