{"metadata":{"accession":"A0A3Q0E7B0","id":"A0A3Q0E7B0_CARSF","source_organism":{"taxId":"1868482","scientificName":"Carlito syrichta","fullName":"Carlito syrichta (Philippine tarsier)"},"name":"Dual specificity protein kinase TTK","description":["Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment"],"length":852,"sequence":"MESEDISGRELTIDSIMNKVRDIKNKFKHEDLTDELSLNKVSTDTTDNSGTVNQIMMMANNPEDWLNLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHVSFAQFELSQGNFKKSKQLLQKAIERGAVPLEMLEIALRNLNLQKKQLLSEEEKNNLSASTALNAQESFSSSLGHSQNRNLGCDSRGQAAKARFSYGENMPPQDAEIGHRNPLKQSNKTKRSCPFGRVPVNLLNSPDCDMKTDGSAAPSLIKRQTAKPECRNLVVPGSKSSGNDASELRNLKSVQNIHSKETLVSDEKSSELTTDSITLKNKIEPSLLTRLEEAKVHQEPKVPESHQKQWQSKRTSECVSQNPVASSNPWQIPELTPKVDTEQKHTIFEQPVLPVSKQSPPVSAPKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPAGQLSTPFGHLACLPQPQQQTPATPLQSLQISASLSTNECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTIDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPQSDVWSLGCILYYMTYGKTPFQHIVNQISKLHAIIDPNHEVEFPDIPEKDLQDVLKRCLIRNPKQRISIPELLAHPYVQIQTHRDHQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHDSSASKTFGKK","proteome":"UP000189704","gene":"TTK","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726173b0dde7bbc50c5d845a39c992d18faf18f3","counters":{"domain_architectures":887312,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"cdd":1,"smart":1,"profile":1,"pfam":1,"panther":1,"prosite":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":887312}}}