{"metadata":{"accession":"A0A3P9Q580","id":"A0A3P9Q580_POERE","source_organism":{"taxId":"8081","scientificName":"Poecilia reticulata","fullName":"Poecilia reticulata (Guppy)"},"name":"Homeobox-containing protein 1","description":["Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres"],"length":508,"sequence":"MSDFSEEPRFTIEQIDLLQRLRRTGMTKQEILHALDTLDRLDREHGDKFGHRTSSSSSSSSTYLVGGANSSAAKTTATSFNNNATASATTTTTSSSATCNGGEGGDHSSSSLVVAAAVASSTTSKISTATQTQFNNSGGGLSPSPSNSYDTSPPPGPPPPSAVLPSPVALVALSQNGRDSLAATPNGKLSPPRYPVNSAAASRAFGFEAAEEDLDVDDKVEELMRRDSSLVKEEIKAFLGNRRISQAVVAQVTGISQSRISHWLLQHGSDLSEQKKRAFYRWYILEKTTPGATLNMRPAPLPLEEMEWRQTPPPLATAPGTFRLRRGSRFTWRKECLAVMESYFNDNQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEATILESHGIDVQSPGGHSNSDDIDGNDFAEQACDLPYFDKRPLSRPFGLYRLEPTSPTQDDSAAHNEHQDPISLAVEMAAVNHTILALSRTGGVPSDIKTESLEDE","proteome":"UP000242638","gene":null,"go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003691","name":"double-stranded telomeric DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045893","name":"positive regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"de2678440553a1f72bdfc874e5dac29c3de3c03e","counters":{"domain_architectures":131,"entries":21,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":3,"cathgene3d":2,"ssf":2,"cdd":2,"smart":1,"pfam":2,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":131}}}