{"metadata":{"accession":"A0A3P9AQT7","id":"A0A3P9AQT7_9CICH","source_organism":{"taxId":"106582","scientificName":"Maylandia zebra","fullName":"Maylandia zebra (zebra mbuna)"},"name":"7-dehydrocholesterol reductase","description":["Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation"],"length":472,"sequence":"METTRRRPQHSANGKRSEQKEQLAQWGRAWEVDWFSLISVIGLLCFAPFIVFYFVMACDQYECSITQPVLDLYQGEATLLSIWARAPSFSWSAAKIYAIWVSFQVFLYMCFPDITHKFIPGYVGGVQEGARTPAGLINKYEINGLQCWLITHALWFANAHYFHWFSPTIIFDNWIPLLWCTNILGYAVSTFAFIKAHLFPTNAEDCKFTGNIFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYMAKQQELYGYITNSMILVNVLQAIYVLDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSDAHALAVLLLGLVGYYIFRSTNHQKDLFRRTEGSCSIWGRKPTWIECTYRSADGGMHRSKLLTSGFWGVARHFNYTGDLMGSLAYCASCGFGHILPYFYIVYMTILLVHRCVRDEHRCSSKYGKDWKRYTDAVPSRLIPGVF","proteome":"UP000265160","gene":null,"go_terms":[{"identifier":"GO:0016628","name":"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016126","name":"sterol biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9a69035bc8c6d4031bf06ea0caf3992496028c64","counters":{"domain_architectures":10044,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"panther":1,"pfam":1,"prosite":2,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":10044}}}