{"metadata":{"accession":"A0A3P9AJW3","id":"A0A3P9AJW3_ESOLU","source_organism":{"taxId":"8010","scientificName":"Esox lucius","fullName":"Esox lucius (Northern pike)"},"name":"Eukaryotic translation initiation factor 3 subunit C","description":["Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation","Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression"],"length":1011,"sequence":"MSRFFATGSDSESEESSSADEITPKAPGTTFTKQSLLLSDDEEDTKRVVRSAKDKRFEELTNLIKTIRNAMKIRDMSKCLEEFEQLCRAFLKSKTIVDKEGVPPFYIRILADLEDYLNQLWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDYETEIASYKENPMASADEEEEKDEVESGSSSDSDDEPADAKSFLKKKSATEAPPPNASKFLKGAADEESSSSDGDNEDWDSDTSESDSGSEDETGRSTSMAVNFLKKTSSEGDRHTSEKKKEERKKRHKRKERIEEEAEEEAQEEGEGEWEKVKGGVPLVKMFAKGTEINTTVVVKKLNEILQARGKKGTDRAAQIELLHALANISNENNLGEGILVKIKFNIIASLYDYNPNLAAFMKADMWKKCLDCIDELLDILFNNDKIFIGENIAEDSENLASDSQEYRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVDNLKDEGRVCGIIDRLMAYLEMETKGSTEEVCRVYLRRIMHTYYKFDYKAHRRALGLQGETKSEQDAEESEGEDSAFIMDRLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGMIKDAHNALLDIQSSGRAKELLGQGLLMRNMQERNAEQEKIEKRRQVPFHMHINLELLECVYLVSAMLLEIPYMAAHEFDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWRTCHSFIINEKMNSKVWDLFPETQCVREMLVRKIQEESLRTYLFTYSSVYDSISMETLKEMFELELPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTSLQNMALQLAEKLGGLVENNERVFDLKQGVYGGYFNRDQKGGYQQKQGGYNRDQRGSYQQKQGGYNRDGQRGGYQQKQGGYNRDGGGYQRQGGYNRDGGGYQQRQGGYNRDGNRGGGGGYQGQNRGGYQGGGGYQGGGGYQGGGGGGYRGGYKGGYQNQDRRDY","proteome":"UP000265140","gene":"EIF3C","go_terms":[{"identifier":"GO:0003743","name":"translation initiation factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0031369","name":"translation initiation factor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006413","name":"translational initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005852","name":"eukaryotic translation initiation factor 3 complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b8cbb0652b42f1e7f5dab84eb4b92abfe634dfb9","counters":{"domain_architectures":3067,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"profile":1,"ssf":1,"smart":1,"hamap":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":3067}}}