{"metadata":{"accession":"A0A3P8Z4B5","id":"A0A3P8Z4B5_ESOLU","source_organism":{"taxId":"8010","scientificName":"Esox lucius","fullName":"Esox lucius (Northern pike)"},"name":"Rap guanine nucleotide exchange factor 4","description":["Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2"],"length":978,"sequence":"MISPKMVAAHTPGHSSASAEWIICLDKRPAERSGEDVDIILSRLKRVKAFERFHPSLLQQICLCGFYECLEKGITLYRQGDTGTSWYAVLSGSLDVKVSETANHQDAVIICTLGIGTAFGESVLDNTPRHATIVTREFSELLRIDQREFKSLWEKYRRCMAGLLAPPYGVMESGGPSTDRMPDKENISNNSCVSISKHLNKVPSEKILRAGKVLRDAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWQMQHSSCVHSRNQAVGMWQVLLEEGVLNHVDQEPTFQDKYLFYRFLDDEKEDAPLPTEEETRENQEELQDTLLLLSQIGPDAHMRMILRKQPGQRTADDLEIIYEELLHIKALSHLSTSVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRSASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKSPSSSSRTSTYTVMSGTPEKILEHFLEMMRLDSDLNESPDAVASQGSEQERLDYALNNKRRVIRMVLRWAGVHGDQLQEEDVSLAFLEEFFESVCDDASVIPALKDQLPELENIVKKQKHICLAVLFQHKVLLRQFSMGDEKLQKRVPIKSHDEILFKVHCSDHTYTTIRVPVAASVREVVSAVADKLGSAEDLLLVNLSSAGGEKVVLKPNDISVFSTLSINGRLFVCPRDQLDSLTPLPEQEGPTAGSMASFELMSSKDLAYQMTVYDWELFHCVHEHELIYHTFGRQNFQKTTANMDLFLRRFNEIQLWVITEICLCAQLSKRVQLVKKFIKIAAHCKEYKNLNSFFAIIMGMSNPAVSRLSQTWEKLPSKFRKFYSEFESLMDPSRNHRVYRLTVAKLDPPIIPFMPLLIKDMTFTHDGNKTFTDSLVNFEKMRMIANTVRIVRYCRSLPFKPSQTSKNHPDVRSYVRQLAVIDNQRTLSQLSQRLEPRRT","proteome":"UP000265140","gene":"RAPGEF4","go_terms":[{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007264","name":"small GTPase-mediated signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"69a338f809e0d08803848d60e48b8cfaaaf60d61","counters":{"domain_architectures":227,"entries":36,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":4,"profile":3,"cdd":3,"smart":3,"pfam":3,"panther":1,"prints":1,"prosite":1,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":227}}}