{"metadata":{"accession":"A0A3P8YSL2","id":"A0A3P8YSL2_ESOLU","source_organism":{"taxId":"8010","scientificName":"Esox lucius","fullName":"Esox lucius (Northern pike)"},"name":"Arrestin domain-containing protein 3","description":["Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes"],"length":416,"sequence":"MVLGKVKSFIISYDCHNESNVPVFASGDSVSGRVIIEVTGEIRVKSLQIYAKGFAKVRWTESRNAGSNTAYTQNYTEEVEYLNHTDILIGHERDDDNCEEGLTTIHSGRHEYAFSLELPQTPLATSFEGKHGSVRYWVKAELHRPWLLPMKTKKEFTVFEHIDINTPLLLSPLAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQTFYAKGKMKEVKQLVANLRGESLSSGKTETWSGKMLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMNLSLNLPLVIGTIPLHTFGSRTSSVSSQCSMTMSWLGMALPERPEAPPSYAEIVTEEQRQRLEVTTARDELEGPLFAYIQEFRFQPPPLYSEVRVVDPNPDQASRTEEQRSDTCPSR","proteome":"UP000265140","gene":null,"go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"59e7dc3418e2699290ec55cb5102b7cea0ac7128","counters":{"domain_architectures":23199,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"smart":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":23199}}}