{"metadata":{"accession":"A0A3P8VPB7","id":"A0A3P8VPB7_CYNSE","source_organism":{"taxId":"244447","scientificName":"Cynoglossus semilaevis","fullName":"Cynoglossus semilaevis (Tongue sole)"},"name":"Eukaryotic translation initiation factor 3 subunit I","description":["Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation","Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression"],"length":325,"sequence":"MKPILLQGHERSITQIKYNREGDLLFSVAKDPVANVWYSVNGGRLGTYNGHTGAVWCVDCDWDTKNVLTGSADNSCRLWDCETGKQLALLHTNSAVRTCGFDFSGNIIMFSTDKQMGYQCFMNFFDLRDPQQIEDNQPYLTIPCSEHKVTSAVWGPLGEFVIAGHENGEINQFSAKSGEVLKKAKEHSRHINDIQTSVDLTMFISASKDNTAKLFDSASLDHIKTFKTERPVNSAAISPSMDHVVMGGGQEAMEVTTTSTRIGTFEARFFHAAYEEEFGRVKGHFGPINCVAFHPDGKSYSSGGEDGYTRIHYFDPQYFDFELEA","proteome":"UP000265120","gene":"EIF3I","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003743","name":"translation initiation factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005852","name":"eukaryotic translation initiation factor 3 complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"79da87310167409b3fbaebcae77583a5bb0e04d9","counters":{"domain_architectures":4489,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"pfam":1,"cathgene3d":1,"ssf":1,"profile":2,"panther":1,"hamap":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":4489}}}