{"metadata":{"accession":"A0A3B5KW06","id":"A0A3B5KW06_9TELE","source_organism":{"taxId":"32473","scientificName":"Xiphophorus couchianus","fullName":"Xiphophorus couchianus (Monterrey platyfish)"},"name":"Translation initiation factor eIF2B subunit gamma","description":["Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed"],"length":454,"sequence":"MELQAVLMAAGGGSRMTDLTYNTPKPMLPVGNKPLMWYPLNLLERVGFEEVIVITTKEVQKMMSTDSKMKRDIKMKMEVVCVPEDGDMGTADALRHIQQKIKTDILVVSCDLITDVALHEVVDLFRAHNATLAMLMSKAHEFTETVPGQKGKKRTAEQRDFVGVDQSGKRLLFMANEADLEDGLSVRKSIIRKHPRMHIKTGLVDAHLYCLKKAVVDFLTENKSISSIRGELVPYLVRKQFSKTTNSQKVKEDLEDQTQKKNDCSTNHELLISSRDEPLLQLAQERSCWNDHRGDMSEAYHGGKLRCYVHIMEQGLCYRVNTLAAYIEANRQAPKLFEEPPVHPSAVISERCQVGSDSIIGERCQIAEKTSIKRSTIGISSNVKEKVKVTNSIVMHSVTIEEGCNIQGSVICSNAIIGRGADLKYCLVGNGQRIEPEVERTNEVIVGTDQLMEI","proteome":"UP000261380","gene":null,"go_terms":[{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"403b674055ea377690b4c62480d9c4419c0c44a2","counters":{"domain_architectures":2805,"entries":12,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":2,"ssf":1,"pfam":2,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":2805}}}