{"metadata":{"accession":"A0A3B5B4Q1","id":"A0A3B5B4Q1_9TELE","source_organism":{"taxId":"144197","scientificName":"Stegastes partitus","fullName":"Stegastes partitus (bicolor damselfish)"},"name":"C2H2-type domain-containing protein","description":["Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11"],"length":477,"sequence":"MATGTQDHRDHVLEKAKLAPFTGRRRRAEGKPKKNFPCQECQKAFNSLEKLKVHSYSHTGERPYRCSHPDCTKAFVSKYKLLRHMATHSPEKNHKCSYCEKMFHRKDHLKNHLHTHDPHKEAFTCQECGKSYNTKLGFKRHLALHAANSGDLTCQVCLQPFPSTGVLLEHLKTHAGKSSGGTKEKKHRCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHARELLRVKTEPADSLEPIVYDLASGSIKGELPGMLTPRPHQLNMYTGPILDTEPFPTSTHPFSLKYPLGSNYTSYTVSSQEREQNLKGDLETYLMELQSSMPSSSSAAQEPQLSSSKLELVPQVGVLEEAGEEVSLSKMSTSVAVTVGDSLASSSSLMDFSQLFNFLPLNGPPYNQVGGSGGQGITFPPNEEPTPLVQLPPQAPTGSEAAESPLQGLPSSFISNLSTPTTLPRFHQAFQ","proteome":"UP000694891","gene":"plag1","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0346a98b137411bfc0f0f13ffd29e20799a8f79d","counters":{"domain_architectures":976,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":2,"smart":1,"profile":1,"ssf":1,"panther":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":976}}}