{"metadata":{"accession":"A0A3B4XDV2","id":"A0A3B4XDV2_SERLL","source_organism":{"taxId":"1841481","scientificName":"Seriola lalandi dorsalis","fullName":"Seriola lalandi dorsalis"},"name":"Thioredoxin-interacting protein","description":["May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1)"],"length":396,"sequence":"MVAMTKRVKTFQITFTDPCKTFYCGGDKVSGRVEVEVNEVTRVSAVKVLGVGRAKVGYAKGKQRCRQEAEYLRYEEVLRLDEQPTDSDGSILLRPGNKYEYTFGFELPQQGQLVSSYKGKFGYVEYFVKALMERPQQPPLECKKPFEVEEPLDVNTPDLLSPTGGMKEKKVTCMFIPDGQVSLNAKIDRRGFCEGEDICINAKFENTCSRIVVPKAAIIAKHTYQANGRTKVFRQKLSSVRGNHIISGMCDAWQGKTIRVPKIKPSMLGCNIIRVEYALMIYIHIPGSEKLILELPLVIGTAGLGSRSNSVSSQEGSVSNSSQSWVSLRMPSEPPSYTDITRDCRLDQPLTPLLDDFDGDDSPIFMTAPAFQFPPPPVYTETEEEYSGNARMLPVC","proteome":"UP000261360","gene":null,"go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"59e7dc3418e2699290ec55cb5102b7cea0ac7128","counters":{"domain_architectures":23199,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"pfam":2,"smart":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":23199}}}