{"metadata":{"accession":"A0A384DHG7","id":"A0A384DHG7_URSMA","source_organism":{"taxId":"29073","scientificName":"Ursus maritimus","fullName":"Ursus maritimus (Polar bear)"},"name":"Phospholipase A1 member A","description":["Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein"],"length":507,"sequence":"MPPGLWERHLCSWGLLLWLSIGSAGDAPSTPQKMCTDFQNVNLLQGTNLKVQFLLFTPLDPSCGQLVQENSDIQNSGFNATLGTKLLIHGFRALGTKPSWIDQFIGTLLRAANANVIAVDWVYGSTGVYFSAVGNVVKLGLEISRFLRKLLELGVPESSIHIIGVSLGAHVGGVVGHLYKGQLGRITGLDPAGPEYTKASLEERLDPGDALFVEAVHTDADNLGIRIPVGHVDYFVNGGQDQPGCPTFIHAGYSYLICDHMRAVHLYISALENSCPFVAFPCVNYKAFLAGQCLDCFNPFLLSCPRIGLMEQSSVKIEPLPKEVKVFLLTTAQAPYCGLCAASHASLLHRLDSTPASHPPSIRRPSTPRASRYCKERSRTLGNSHDECITASWSFICRSQGTRTPSSPSPSLAAMLLPWPRSPCTPRQELQGKGVIAHANPQCQINQVKLKFHSSHRVWRKDRTTIVGKFCTAPLPVNDNKKMVCFPEPVTLQASVTVSFDLKITCV","proteome":"UP000261680","gene":"PLA1A","go_terms":[{"identifier":"GO:0016298","name":"lipase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0052689","name":"carboxylic ester hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4b27ea83a55bae860624d8852585749e0e54f3f6","counters":{"domain_architectures":16973,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"cathgene3d":1,"ssf":1,"cdd":1,"pirsf":1,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":16973}}}