{"metadata":{"accession":"A0A341CSS9","id":"A0A341CSS9_NEOAA","source_organism":{"taxId":"1706337","scientificName":"Neophocaena asiaeorientalis asiaeorientalis","fullName":"Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)"},"name":"Serine/threonine-protein phosphatase 2A activator","description":["PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A"],"length":246,"sequence":"MGKWKRSQAYADYIGFILTLNEGVKGKKLSFEYRVSEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPCLEPRHFVDEKAVNESHKDYMFLECVLFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSC","proteome":"UP000252040","gene":"PTPA","go_terms":[{"identifier":"GO:0019211","name":"phosphatase activator activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"72ff6fad7eb2a23f6de70223ef85ba73d19c8cc3","counters":{"domain_architectures":7072,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"cathgene3d":1,"pirsf":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":7072}}}