{"metadata":{"accession":"A0A340YEW5","id":"A0A340YEW5_LIPVE","source_organism":{"taxId":"118797","scientificName":"Lipotes vexillifer","fullName":"Lipotes vexillifer (Yangtze river dolphin)"},"name":"S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1","description":["Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis"],"length":531,"sequence":"MLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGTEDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHEHKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGASERGFDPKDTRYQRRNKSKDISGC","proteome":"UP000265300","gene":"TYW1B","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051536","name":"iron-sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051539","name":"4 iron, 4 sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008033","name":"tRNA processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8f410f85842070b5c6f55e064c90b55a8cd35bca","counters":{"domain_architectures":1158,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"profile":1,"cdd":1,"pfam":2,"ssf":1,"panther":1,"sfld":3,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":1158}}}