{"metadata":{"accession":"A0A340WTX0","id":"A0A340WTX0_LIPVE","source_organism":{"taxId":"118797","scientificName":"Lipotes vexillifer","fullName":"Lipotes vexillifer (Yangtze river dolphin)"},"name":"Activin receptor type-1-like","description":["Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well"],"length":514,"sequence":"MQMKVLCDGTMTLDPPRRTLLMLLTALGLTQGDPVKPSRGPLVTCTCENPYCKGPTCQGAWCTVVLVREEGTRLQEHRGCGSLNQELCKGRPTEFLNHYCCYSPFCNHNVSLVLEATQTPPEQPQEDGQLPLILGPVLALLVLVALGALGLWHVRRRQEKRRGLNSELGESSLILKPSEQGDSVLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKVFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLEEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKAVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSNGLQRPKVTH","proteome":"UP000265300","gene":"ACVRL1","go_terms":[{"identifier":"GO:0004675","name":"transmembrane receptor protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007178","name":"cell surface receptor protein serine/threonine kinase signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1e61f7f86bb83ce3339cf1259306c7a095592c49","counters":{"domain_architectures":1624,"entries":24,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"cdd":2,"ssf":2,"profile":2,"smart":2,"pfam":2,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1624}}}