{"metadata":{"accession":"A0A315V709","id":"A0A315V709_GAMAF","source_organism":{"taxId":"33528","scientificName":"Gambusia affinis","fullName":"Gambusia affinis (Western mosquitofish)"},"name":"Bifunctional purine biosynthesis protein ATIC","description":["Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization"],"length":591,"sequence":"MASTELALLSVSDKTGLVDFAKRLVNVGLSLVGSGGTAKALRDAGLAVRDVSELTGHPEMLGGRVKTLHPAVHGGILARKSASDSADMEKLGYSLVRVVVCNLYPFVKTISSPNVTVEDAVEQIDIGGVTLLRAAAKNHARVTIVCDPADYSLVAKEMENSGHKDTTLETRRTLALKAFTHTAQYDEAISDYFRGQYSRGVSQLPLRYGMNPHQAPAQIFTLRSELPLKVANGSPGFINLCDALNAWQLVRELKAALGVAAATSFKHVSPAGAAVGVPLSEEEAKVCMVHDMLKDLTPLATAYARARGSDRMSSFGDFIALSDVCDVPTAKIISREVSDGIIAPGYEEEALKILSKKKNGNYCVLQMDPDYEPDSTEVRVLFGLYLKQKRNGALINKEFFRNVVSEGSLSEDALRDLTVATIAVKYTQSNSVCYAKAGQVIGIGAGQQSRIHCMRLAGEKADNWWLRHHPRVLSMKFRGGVKRAEMANAIDQFVSDTVGEGPDLDVWKSMYDEVPEFLSATEKKNWISSLQGVAVSSDAFFPFRDNIDRAKRSGVEYIAAPAGSAADEVVINACNELGITLVHTSLRLFHH","proteome":"UP000250572","gene":"CCH79_00004961","go_terms":[{"identifier":"GO:0003937","name":"IMP cyclohydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004643","name":"phosphoribosylaminoimidazolecarboxamide formyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006164","name":"purine nucleotide biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4c4a53bb5204d60810708c65aa3b11581b73dfb8","counters":{"domain_architectures":28631,"entries":22,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":3,"cdd":1,"ssf":2,"pfam":2,"smart":2,"pirsf":1,"hamap":1,"panther":1,"ncbifam":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":28631}}}