{"metadata":{"accession":"A0A2Y9T4V4","id":"A0A2Y9T4V4_PHYMC","source_organism":{"taxId":"9755","scientificName":"Physeter macrocephalus","fullName":"Physeter macrocephalus (Sperm whale)"},"name":"Cholesterol transporter ABCA5","description":["Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes"],"length":1642,"sequence":"MATAIREVGVWRQTRTLLLKNYLVKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPDMELNPMDKSILSNVILGFTPVTNITRDIMQKVSTDHLPNVIITEEYTSEKELLTASLSKSSNFVGVVFNDFMSYELRFFPDMIPVSSVYMDSRAGCSESCEAVQYWSSGFTVLQASIDAAIIQLKTNVSFWKELEPTKAVLMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIAAEKEKKLKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASSLFPQSSCFVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFLVTVAFGFVGLLIVLMESFPKSLVWLLSPFCQCTFLIGIAQVMHLEDFNEGALFSNLTEGPYPLIITVIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSFYFLKPSYWSKSRRNYKELSEGNVSGNISFSEIVEPVSSEFKGKEAIRISGIQKTYRKKGENVEALRSLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASVYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLTILASIKGVPANNVIQEVQKVLLDLDMQAIKDNQAEKLSGGQKRKLSVGIAVLGNPKVLLLDEPTAGMDPCSRHIVWNLLKCRKANRVTVFSTHFMDEADILADRKAVMSQGMLKCVGSSIFLKSKWGIGYRLSMYIDRNCATESLSSLVKQHIPAATLLQQSDQQLVYSLPFKDMDKFSGLFAALDTHSDLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPPEEELHSKPFDEMEQSLLILSETKASLVSTMSVWKQQVFKIAKFHFLTLKRESKSVRSVLLLLLIFFAVQIFMFLVHHSFKNAAVPVKLVPDLYFLKPGDKPDKYRTSLLLQNSTDSDISDLLSFFTNQSIMVTMFNDSDYVSAAPHSAALNVMQSEKDYVFTAVFNSTMVYSLPVLMNIISNYYLYHSNVTESIQVWNTPFVQGITDIVFKIELYFQAALLGVIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQALVDVPLFSVVLTLMLGSLFSFHHGLYFYAVKFLSVVFCLIGYVPSVILFTYITSFTFKKIVNTREFWSFIYSVTALACIAVTEITYFMGYTVTVILHYALCIAIPIYPLLGCLICFIKISWKNIQKKEDTYNPWDSLLVAVISPYLQCVLWIFLLQYYEKKYGGRSLRKDPFFRTLTTKSKSRKFPEPPNNVDEDEDVRAERVKVKELLSCQHHEEKPAIMVNNLHKEYEDKRDFLLTRKIKKVANKYVSFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSDPAGDDDSVKCMGYCPQINPLWPEITLQEHFEIYGAVKGMSASDMKEVIIRITNALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPPVTLLDEPSTGMDPKAKQHMWSAIRAAFNNKKRAAILATHCMEEVEAVCDRVAILVSGRLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQHIFPNASRQESFSSILAYKIPKEDVQSLSQSFSKLEEAKHTFAIEEYSFSQATLEQVFVELTKEQEEDDNTCGTSNSTLRWERTQEDRVVF","proteome":"UP000248484","gene":"ABCA5","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016887","name":"ATP hydrolysis activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140359","name":"ABC-type transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"ee60307872d0674dd1126830c2f5552323a1ff89","counters":{"domain_architectures":875,"entries":18,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"profile":1,"pfam":4,"smart":1,"panther":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":875}}}