{"metadata":{"accession":"A0A2Y9RYR5","id":"A0A2Y9RYR5_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"CD27 antigen","description":["Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue"],"length":265,"sequence":"MAWPPPCWLWVLGTLVGLSAAPGPKGCPERHYQAQGDLCCQMCEPGTFLVKDCDRHGKAAQCEPCVPGVSFSPDHHTRPHCESCRHCNFGLRIRNCTITANAECACPNGWQCRDKECTECDQLPNTLLTRLPQAPGPHPQSTSLPYAEKMAEARSIRPMQTLAHSRWLPAPARSTHWPSQRSLCSSDCIRIFVVLSGMLLVFTLGGVLFLHQQRKYGSNKRESPMEPAEPCAYSCPREEEGGAIPIQEDYRKPEPVIYPLEKVAL","proteome":"UP000248480","gene":"CD27","go_terms":[{"identifier":"GO:0045579","name":"positive regulation of B cell differentiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045582","name":"positive regulation of T cell differentiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043066","name":"negative regulation of apoptotic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"smart":1,"ssf":1,"cathgene3d":1,"profile":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1}}}