{"metadata":{"accession":"A0A2Y9Q460","id":"A0A2Y9Q460_DELLE","source_organism":{"taxId":"9749","scientificName":"Delphinapterus leucas","fullName":"Delphinapterus leucas (Beluga whale)"},"name":"NADPH oxidase organizer 1","description":["Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity"],"length":360,"sequence":"MAGPRHPVSVSGAALVQTDRLQTFAFSVCWSDDSDTFARRSWEEFRRLHKTLKETFPVEAGLLRRSDRILPKLTDASLLVHWGHTGRGLARLQLLETYSRALLAAGERVTHSPVLTGFFAPQPMDLEPVLPAGSLVILPAPQEPLPGPTGSPAIRSQEAQSLHCLQPFSTQDTWGQPFHARAQEALDVLLRHPSGWWLVANEDQQMAWFPAPYLEELALGQGRDGEWSLGSSGYQFCASHAYESSQADELSVTTGARVRVLETSDCGWWLCRFRGRTGLLPAAILQPDGLGTLLSGPWLHLRVDGGEDREGEAQSSPKSPQATTLPPTVPARPSRSAIQSCCCTITRKALEQYPGCHGPP","proteome":"UP000248483","gene":"NOXO1","go_terms":[{"identifier":"GO:0035091","name":"phosphatidylinositol binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"13cb3d8a7f40c48d73e8b47e975aa49213f57f67","counters":{"domain_architectures":8980,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":2,"ssf":2,"smart":1,"pfam":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":8980}}}