{"metadata":{"accession":"A0A2Y9G0W9","id":"A0A2Y9G0W9_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"FXYD domain-containing ion transport regulator","description":["Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone"],"length":93,"sequence":"MTSLSHIIFVLCVGLLTMANAEAPQEHDPFTYDYQSLRIGGLIIAGILFILGILIILSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSSRRR","proteome":"UP000248480","gene":"FXYD1","go_terms":[{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0099106","name":"ion channel regulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043269","name":"regulation of monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"a6b0f0c4b2168d3a7a214e17be666e81b4d7355c","counters":{"domain_architectures":3740,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"panther":1,"pfam":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":3740}}}