{"metadata":{"accession":"A0A2Y9ESY9","id":"A0A2Y9ESY9_PHYMC","source_organism":{"taxId":"9755","scientificName":"Physeter macrocephalus","fullName":"Physeter macrocephalus (Sperm whale)"},"name":"Docking protein 1","description":["DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3"],"length":481,"sequence":"MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWALAPAENPPKLSALEMLENSLYSPAWEGSQFWVTVQRTEAAERCGLHGSYMLRVEAERLTLLGVGAQSQIQEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKASQGQDVLRADSHEGEVAEGKLAPHRGPQELAGSTPALYAEPLDSLRILPGPSQDSVYSDPLDSTPAQAGEGLKKPLYWDLCEHVQQQLIKAKLTDPKEDPIYDEPEGLAPAALRGLYDLPQEPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRCTKPFPAPKPQGLAFSESGAAAGSGSKGHSSDAALYSQVQKSGASGSWDCGLSGAGTDRTGAKSEGST","proteome":"UP000248484","gene":"DOK1","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c8a40e550b300634ec01479500bc4ee8471809d5","counters":{"domain_architectures":4665,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":3,"pfam":2,"cdd":1,"profile":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":4665}}}