{"metadata":{"accession":"A0A2X5C3U8","id":"A0A2X5C3U8_SALET","source_organism":{"taxId":"59201","scientificName":"Salmonella enterica I","fullName":"Salmonella enterica I"},"name":"Ketol-acid reductoisomerase (NADP(+))","description":["Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate"],"length":491,"sequence":"MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRSVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQFEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGSAIPEGAVDNAQLRDVNDAIRSHAIEQVGKKLRGYMTDMKRIAVAG","proteome":null,"gene":"ilvC","go_terms":[{"identifier":"GO:0004455","name":"ketol-acid reductoisomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009082","name":"branched-chain amino acid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a416217ffe9aa75be53b7150059dcaafe5ce3978","counters":{"domain_architectures":4251,"entries":18,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":2,"ssf":2,"pfam":2,"panther":1,"ncbifam":2,"hamap":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":4251}}}