{"metadata":{"accession":"A0A2W1BM47","id":"A0A2W1BM47_HELAM","source_organism":{"taxId":"29058","scientificName":"Helicoverpa armigera","fullName":"Helicoverpa armigera (Cotton bollworm)"},"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","description":["Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation"],"length":289,"sequence":"MKLQTSSKIVASFLTDLKKRFSLRSLCTYLHMFVRDYVKFGRNDFETVFSKHVAALDVDITNGKVLEEELNTKYGENKVRFHKCDVTTNELDAVYDNVVNDFGYIDVVINCAGIMNDRPNVYLKEIDINVTALIKSSFKAFDLMRKDQGGRGGTIINISSIVGLFQAHLLPVYTATKSAVLQFSNCLGMEPHSTRSGVRVLTLCFGCTDTSLFSATKMGAFDKETDELLFGSLGKLPLQTIQSAVDGLIHAYKHGASASTWLVTSDRPAEDITGNVSKAYEIMSQGVFS","proteome":"UP000249218","gene":"HaOG206408","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a0c95b509a3fe852564663f48768d986938c9d65","counters":{"domain_architectures":599639,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"prosite":1,"prints":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":599639}}}