{"metadata":{"accession":"A0A2U9C7U1","id":"A0A2U9C7U1_SCOMX","source_organism":{"taxId":"52904","scientificName":"Scophthalmus maximus","fullName":"Scophthalmus maximus (Turbot)"},"name":"Phosphodiesterase","description":["Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory"],"length":509,"sequence":"MGSASSSYRVIYLDVEGRTQKVVFSRFCSPCDIKDLFCTALGVPRNTNLSLLDSSGAMVSIDPTMPHNTERSPYRVLPMTGGQLADKEELFQNVLTQVAEQFSRAFKINELKSEVTNRLAMLEKRVELEGMKVVEIEKCRTDIKKLRVEMASRNNSNFLEDTKKLTPRRDVPSYPKYMLSEQTIEALKKPAFDVWLWEANEMLSCLEHMYHDLGLVTDFNINPITLKRWLLSIHDNYKNNPFHNFRHCFCVTQMMYSMICLCSLQEKFTQVDILILMTAAVCHDLDHPGFNNTYQINARTELAVRYNDISPLENHHCAVAFQIFSQPDCNIFSSFDPEAFKQLRQGTITLILATDMARHGEILDSFKQKVDSFDFTDEEHATCLKMVLIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKTEGLPVAPFMDRERVTKPTAQIGFIKFVLIPMFESVMKLFPQIEEAMVQPLRESRDRYEELKQIDDAMNEVQKKKSESLTMGGKKK","proteome":"UP000246464","gene":"PDE9A","go_terms":[{"identifier":"GO:0004114","name":"3',5'-cyclic-nucleotide phosphodiesterase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"55c76fe585d3fb9c71ce12a59464e90a49687b13","counters":{"domain_architectures":20360,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"ssf":1,"smart":1,"pfam":1,"cdd":1,"panther":1,"prints":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":20360}}}